PUBLICATIONS: REFEREED JOURNALS:

Wostmann, B.S., Knight, P.L., Keeley, L.L. and Kan, D.F. (1963) Metabolism and function of thiamine and naphthoquinones in germfree and conventional rats. Federation Proceedings 22, 120-124.

Keeley, L.L. and Friedman, S. (1967) The corpus cardiacum as a metabolic regulator in Blaberus discoidalis Serville (Blattidae). I. Long-term effects of cardiacectomy on whole body and tissue respiration and on trophic metabolism. General and Comparative Endocrinology 8, 129-134.

MacFarlane, J.J. and Keeley, L.L. (1969) Heat effects on the infectivity of the nuclear polyhedrosis virus of Heliothis spp. Journal of Economic Entomology 62, 925-929.Keeley,

L.L. and Friedman, S. (1969) Effects of long-term cardiacectomy-allatectomy on mitochondrial respiration in the cockroach, Blaberus discoidalis. Journal of Insect Physiology 15, 509-518.

Keeley, L.L. (1970) Diapause metabolism and rearing methods for the white-lined sphinx, Celerio lineata (Lepidoptera; Sphingidae). Annals, Entomological Society of America 63, 905-907.

Keeley, L.L. (1970) Insect fat body mitochondria: endocrine and age effects on respiratory and electron transport activities. Life Sciences 9, 1003-1011.

Keeley, L.L. (1971) Endocrine effects on the biochemical properties of fat body mitochondria from the cockroach, Blaberus discoidalis. Journal of Insect Physiology 17, 1501-1515.

Keeley, L.L. and Waddill, V.H. (1971) Insect hormones: evidence for a neuroendocrine factor affecting respiratory metabolism. Life Sciences 10 (II), 737-745.

Keeley, L.L. (1972) Biogenesis of mitochondria: neuroendocrine effects on the development of respiratory functions in fat body mitochondria of the cockroach Blaberus discoidalis. Archives of Biochemistry and Biophysics 153, 8-15.

Shepard, M. and Keeley, L.L. (1972) Circadian rhythmicity and capacity for enforced activity in the cockroach, Blaberus discoidalis, after cardiacectomy-allatectomy. Journal of Insect Physiology 18, 595-601.

Waddill, V.H. and Keeley, L.L. (1972) Effects of DDT on biochemical functions of fat body and muscle mitochondria isolated from the cockroach. Pesticide Biochemistry and Physiology 1, 453-457.

Keeley, L.L. (1973) Characterization of insect fat body mitochondria isolated by a rapid procedure. Comparative Biochemistry and Physiology 8, 147-151.

Keeley, L.L. (1974) Feeding effects on neuroendocrine regulated development of fat body mitochondria in Blaberus discoidalis. Journal of Insect Physiology 20, 1249-1255.

Keeley, L.L. (1975) Neuroendocrine deficiency effects on trophic metabolism and water balance in the cockroach, Blaberus discoidalis. Journal of Insect Physiology 21, 501-510.

Keeley, L.L. and Vinson, S.B. (1975) B-ecdysone effects on the development of nucleopolyhedrosis in Heliothis spp. Journal of Invertebrate Pathology 26, 121-123.

Holmes, E.A. and Keeley, L.L. (1975) Mitochondrial development in the flight muscles of Heliothis virescens (Lepidoptera). Insect Biochemistry 5, 15-24.

Holmes, E.A. and Keeley, L.L. (1975) Metabolic inhibitors: effects on metamorphosis and flight muscle mitochondrial development in the moth, Heliothis virescens. Insect Biochemistry 5, 349-355.

Keeley, L.L., Moody, D.S., Lynn, D., Joiner, R.L., and Vinson, S.B. (1977) Succinate-cytochrome c reductase activity and lipids in diapause and non-diapause Anthonomus grandis Boh. from different latitudes. Journal of Insect Physiology 23, 231-234.

Keeley, L.L. and Olson, J.K. (1977) Toxic effects of mitochondrial DNA inhibitors on insect growth and development. Journal of Insect Physiology 23, 303-307.

Keeley, L.L. (1977) Developmental and endocrine regulation of cytochrome levels in fat body mitochondria of the cockroach, Blaberus discoidalis. Insect Biochemistry 7, 297-301.

Keeley, L.L. (1978) Development and endocrine regulation of mitochondrial cytochrome biosynthesis in the insect fat body. d-aminolevulinic acid synthase. Archives of Biochemistry and Biophysics 187, 79-86.

Keeley, L.L. (1978) Development and endocrine regulation of mitochondrial cytochrome biosynthesis in the insect fat body. d-[14C]aminolevulinic acid incorporation. Archives of Biochemistry and Biophysics 187, 87-95.

McDaniel, S.G., Keeley, L.L. and Sterling, W.L. (1978) Radiolabeling Heliothis virescens eggs by 32P injection of adult females. Annals, Entomological Society of America 71, 432-434.

Mannix, J.J. and Keeley, L.L. (1980) Age and endocrine effects on fat body metabolite composition in adult male Blaberus discoidalis cockroaches, Journal of Experimental Zoology 212, 113-117.

Hayes, T.K. and Keeley, L.L. (1981) Cytochromogenic factor: a newly-discovered neuroendocrine agent stimulating mitochondrial cytochrome synthesis in the insect fat body. General and Comparative Endocrinology 45, 115-124.

Gruetzmacher, M.C. and Keeley, L.L. (1982) Cytochrome degradation and synthesis in fat body mitochondria during diapause, diapause termination and metamorphosis of Heliothis zea. Insect Biochemistry 12, 49-54.

Wagner, T.L., Fargo, W.S., Keeley, L.L., Coulson, R.N. and Cover, J.D. (1982) Effects of sequential attack on gallery construction, oviposition and re-emergence by Dendroctonus frontalis (Coleoptera: Scolytidae). Canadian Entomologist 114, 491-502.

Keeley, L.L. (1983) RNA and protein biosynthesis in the fat body of dormant pupae and pharate adult Heliothis zea. Comparative Biochemistry and Physiology (B) 75, 127-132.

Hilliard, R.A. and Keeley, L.L. (1983) Development and endocrine effects on mitochondrial protein synthesis in the fat body of the cockroach, Blaberus discoidalis. Insect Biochemistry 13, 199-204.

Lawson-Smith, E., Hayes, T.K. and Keeley, L.L. (1983) Isolation of neurosecretory granules containing cytochromogenic hormone activity from the corpora cardiaca of Blaberus discoidalis cockroaches. General and Comparative Endocrinology 52, 149-156.

Hayes, T.K. and Keeley, L.L. (1984) Patterns and control of neurosecretion for the cytochromogenic hormone in Blaberus discoidalis cockroaches. Journal of Experimental Biology 107, 49-58.

Hilliard, R.A. and Keeley L.L. (1984) The effects of dietary nitrogen on reproductive development in the female boll weevil, Anthonomus grandis. Physiological Entomology 9, 165-174.

Hilliard, R.A and Keeley, L.L. (1984) Interactions between dietary nitrogen and simulated autumn conditions on diet consumption and reproductive development in the boll weevil, Anthonomus grandis. Physiological Entomology 9, 417-423.

Keeley, L.L. and McKercher, S.R. (1985) Endocrine regulations of ovarian maturation in the cockroach, Blaberus discoidalis. Comparative Biochemistry and Physiology (A) 80, 115-121.

Hayes, T.K. and Keeley, L.L. (1985) Properties of in vitro bioassay for hypertrehalosemic hormone of Blaberus discoidalis cockroaches. General and Comparative Endocrinology 57, 246-256.

Hayes, T.K., Keeley, L.L. and Knight, D.W. (1986) Insect hypertrehalosemic hormone: Isolation and primary structure from Blaberus discoidalis cockroaches. Biochemical Biophysical Research Communications 140, 674-678.

Keeley, L.L. and Hayes, T.K. (1987) Speculations on biotechnology applications for insect neuroendocrine research. (Mini-Review). Insect Biochemistry 17, 639-651.

Dover, B.A., Davies, D.H., Strand, M.R., Gray, R.S., Keeley, L.L. and Vinson, S.B. (1987) Ecdysteroid titer reduction and developmental arrest of last instar Heliothis virescens larvae by calyx fluid from the parasitoid Campoletis sonorensis. Journal of Insect Physiology 33, 333-338.

Chan, S.-M., Rankin, S.M. and Keeley, L.L. (1988) Characterization of the molt stages in Penaeus vannamei: Setogenesis and hemolymph levels of total protein, ecdysteroids and glucose. Biological Bulletin 175, 185-192.

Keeley, L.L.,Sowa, S.M., Hayes, T.K. and Bradfield, J.Y. (1988) Neuroendocrine and juvenile hormone effects on ovarian maturation and protein synthesis by the in vitro fat body from adult female Blaberus discoidalis cockroaches. General and Comparative Endocrinology 72, 364-373.

Quackenbush, L.S. and Keeley, L.L. (1988) Regulation of vitellogenesis in the fiddler crab, Uca pugilator. Biological Bulletin 175, 321-331.

Chung, J.-S. and Keeley, L.L. (1989) Evidence and bioassay for diuretic factors in the nervous system of larval Heliothis virescens (F.). Journal of Comparative Physiology 159, 359-370.

Rankin, S.M., Bradfield, J.Y. and Keeley, L.L. (1989) Ovarian protein synthesis in the South American White Shrimp, Penaeus vannamei, during the reproductive cycle. International Journal of Invertebrate Reproduction and Development 15, 27-33.

Bradfield, J.Y. and Keeley, L.L. (1989) Adipokinetic hormone gene sequence from Manduca sexta. Journal of Biological Chemistry 264, 12791-12793..

Bradfield, J.Y., Berlin, R.L., Rankin, S.M. and Keeley, L.L. (1989) Cloned cDNA and antibody for an ovarian cortical granule polypeptide of the shrimp, Penaeus vannamei. Biological Bulletin 177, 344-349.

Bradfield, J.Y., Berlin, R.L. and Keeley, L.L. (1990) Contrasting modulations of gene expression by juvenile hormone. Insect Biochemistry 20, 105-111.

Hayes, T.K. and Keeley, L.L. (1990) Structure-activity relationships on hyperglycemia by representatives of the adipokinetic/hyperglycemic hormone family in Blaberus discoidalis cockroaches. Journal of Comparative Physiology 160(B), 187-194.

Chan, S.M., Rankin, S.M. and Keeley, L.L. (1990) Effects of 20-hydroxyecdysone injection and eyestalk ablation on the moulting cycle of the shrimp, Penaeus vannamei. Comparative Biochemistry and Physiology 36A, 205-209.

Keeley, L.L., Hayes, T.K. Bradfield, J.Y. and Sowa, S.M. (1991) Physiological actions by hypertrehalosemic hormone and adipokinetic peptides in adult Blaberus discoidalis cockroaches. Insect Biochemistry 21, 121-129.

Bradfield, J.Y., Lee, Y.-H. and Keeley, L.L. (1991) Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by hypertrehalosemic hormone. Proceedings of the National Academy of Sciences, U.S.A. 88, 4558-4562.

Keeley, L.L., Chung, J.-S. and Hayes, T.K. (1992) Diuretic and antifeedant actions by Manduca sexta diuretic hormone in lepidopteran larvae. Experientia 48, 1145-1148.

Lee, Y.-H. and Keeley, L.L. (1994) Hypertrehalosemic hormone effects on transcriptional activity in the fat body of the cockroach, Blaberus discoidalis. Insect Biochemistry and Molecular Biology 24, 357-362.

Lee, Y.-H. and Keeley, L.L. (1994) Intracellular transduction of trehalose synthesis by hypertrehalosemic hormone in the fat body of the tropical cockroach, Blaberus discoidalis. Insect Biochemistry and Molecular Biology 24, 473-480.

Keeley, L.L., Sowa, S.M. and Hesson, A.S. (1995) In vitro bioassay for hypertrehalosemic hormone-dependent trehalose biosynthesis by fat body from adult Blaberus discoidalis cockroaches. Archives of Insect Biochemistry and Physiology 28, 313-324.

Lu, K.-H., Bradfield, J.Y. and Keeley, L.L. (1995) Hypertrehalosemic hormone-related gene expression for cytochrome P4504C1 in the fat body of the neotropical cockroach, Blaberus discoidalis. Archives of Insect Biochemistry and Physiology 28, 79-90.

Keeley, L.L. and Hesson, A.S. (1995) Calcium-dependent signal transduction by the hypertrehalosemic hormone in the cockroach fat body. General and Comparative Endocrinology 99, 373-381.

Park, J.H. and Keeley, L.L. (1995) In vitro hormonal regulation of glycogen phosphorylase activity in fat body of the tropical cockroach, Blaberus discoidalis. General and Comparative Endocrinology. 98, 234-243.

Park, J.H. and Keeley, L.L. (1996) Calcium-dependent action of hypertrehalosemic hormone on activation of glycogen phosphorylase in cockroach fat body. Molecular and Cellular Endocrinology 116, 199-205.

Sowa, S.M. and Keeley, L.L. (1996) Free amino acids in the hemolymph of the cockroach, Blaberus discoidalis. Comparative Biochemistry and Physiology 113A, 131-134.

Keeley, L.L., Park, J.H., Lu, K.-H. and Bradfield, J.Y. (1996) Neurohormone signal transduction for dual regulation and gene expression in insects: Hypertrehalosemic hormone as a model. Archives of Insect Biochemistry and Physiology 33, 283-301.

Lu, K.-H., Bradfield, J.Y. and Keeley, L.L. (1996) Age and starvation effects on hypertrehalosemic hormone-dependent gene expression of cytochrome P4504C1 in the cockroach, Blaberus discoidalis. Journal of Insect Physiology 42, 925-930.

Ayali, M., Pener, M.P., Sowa, S.M. and Keeley, L.L. (1996) Adipokinetic hormone content of the corpora cardiaca in gregarious and solitary migratory locusts. Physiological Entomology 21, 167-172.

Sowa, S.M., Lu, K.-H. Park, J.H. and Keeley, L.L. (1996) Physiological effectors of hyperglycemic neurohormone biosynthesis in an insect. Molecular and Cellular Endocrinology 123, 97-105.

Lewis, D.K., Jezierski, M., Bradfield, J.Y. and Keeley, L.L. (1997) Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Molecular and Cellular Endocrinology, 130, 101-108.

Lewis, D.K., Bradfield, J.Y. and Keeley, L.L. (1998) Feeding effects on gene expression of the hypertrehalosemic hormone in a cockroach, Blaberus discoidalis. Journal of Insect Physiology. 44, 967-972.

Park, J.H. and Keeley, L.L. (1998) The effect of biogenic amines and their analogs on carbohydrate metabolism In the fat body of the cockroach Blaberus discoidalis. General and Comparative Endocrinology 110, 88-95.

Lu, K.-H., Bradfield, J.Y. and Keeley, L.L. (1999) Juvenile hormone inhibition of gene expression for cytochrome P4504C1 in adult females of the cockroach, Blaberus discoidalis. Insect Biochemistry and Molecular Biology, 29, 667-673.

Wang, Y. J., Hayes, T.K., Holman, G.M., Chavez, A.R. and Keeley, L.L. (2000) Primary structure of CHH/MIH/GIH-like peptides in sinus gland extracts from Penaeus vannamei. Peptides 21, 477-484.

Pietrantonio, P. V., Jagge, C., Keeley, L. L., and Ross, L. S. (2000) Cloning of an aquaporin-like cDNA and in situ hybridization in adults of the mosquito Aedes aegypti (Diptera: Culicidae). Insect Molecular Biology 9, 407-418.

Lewis, D. K., Campbell, J.Q., Sowa, S.M., Vinson, S.B. and Keeley, L.L. (2001) Characterization of vitellogenin in the red imported fire ant, Solenopsis invicta (Hymenoptera: Apocrita: Formicidae). Journal of Insect Physiology, 47, 543-551.

Lewis, D. K., Campbell, J.Q., Sowa, S.M., Chen, M.-E., Vinson, S. B. and Keeley, L.L. (2002) The biochemical characteristics of vitellogenin in the red imported fire ant, Solenopsis invicta (Hymentoptera: Formicidae). Southwestern Entomologist Supp. 25, 71-79.

Lewis, D.K., Spurgeon, D., Sappington, T. and Keeley, L.L. (2002) A hexamerin protein, AgSP-1, is associated with diapause in the boll weevil. Journal of Insect Physiology 48, 887-901.

Chen, M.-E., Lewis, D.K., Keeley, L.L. and Pietrantonio, P.V. (2004) cDNA cloning and transcriptional regulation of the vitellogenin receptor from the imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae). Insect Biochemistry and Molecular Biology 13, 195-204.

INVITATIONAL REVIEWS AND BOOK CHAPTERS:

Keeley, L.L. (1972) Neuroendocrine Regulation of Insect Metabolism and the Influence of Nutrition. In: Insect and Mite Nutrition, (Ed. Rodriguez, J.G.), pp.541-554, Lexington, KY, North Holland Publ. Co., Amsterdam.

Keeley, L.L. (1978) Endocrine Regulation of Fat Body Development and Function. Annual Review of Entomology 23, 324-352.

Keeley, L.L. (1981) Neuroendocrine Regulation of Mitochondrial Development and Function in the Insect Fat Body. In: Energy Metabolism and Its Regulation in Insects, (Ed. Downer, R.G.H.), pp. 207-237, Plenum Press, NY.

Hayes, T.K. and Keeley, L.L. (1984) The Isolation of Insect Neuropeptides Using Reverse-Phase High Performance Liquid Chromatography. In: Proceedings, International Conference on Insect Neurochemistry and Neurophysiology, (Ed. Borkovec, A.B. and Kelly, T.J.), pp. 223-250, Plenum Press, NY, 523 pgs.

Keeley, L.L. (1985) Biochemistry and Physiology of the Insect Fat Body. In: Comprehensive Insect Physiology, Biochemistry and Pharmacology, (Ed. Kerkut, G.A. and Gilbert, L.I.), vol. 3., pp. 211-248, Pergamon Press, NY.

Hayes, T.K. and Keeley, L.L. (1986) Isolation and Structure of the Hypertrehalosemic Hormone from Blaberus discoidalis Cockroaches. In: Insect Neurochemistry and Neurophysiology - 1986, (Ed. Borkovec, A.B. and Gelman, D.B.), pp. 195-198, Humana Press, Clifton, NJ, 484 pgs.

Keeley, L.L., Sowa, S. and Hayes, T. (1986) Endocrine Regulations of Protein Synthesis by the In Vitro Fat Body from Blaberus discoidalis Cockroaches. In: Insect Neurochemistry and Neurophysiology - 1986, (Ed. Borkovec, A.B. and Gelman, D.B.), pp. 211-214, Humana Press, Clifton, NJ, 484 pgs.

Keeley, L.L. (1986) Overview: Progress in Insect Neurochemistry. In: Insect Neurochemistry and Neurophysiology - 1986, (Ed. Borkovec, A.B. and Gelman, D.B.), pp. 175-178, Humana Press, Clifton, NJ, 484 pgs.

Keeley, L.L. (1988) Potential Applications of Neuroendocrine Research to Insect Control. In: Biotechnology for Crop Protection:, (ed. Hedin, P.A., Menn, J.J. and Hollingworth, R.M.), American Chemical Society Series No. 379, pgs. 147-159.

Ford, M.M., Hayes, T.K. and Keeley L.L. (1988) Structure-Activity Relationships for Insect Hypertrehalosemic Hormone: The Importance of Side Chains and Termini. In: Peptides: Chemistry and Biology, Proceedings of the Tenth American Peptide Symposium, (Marshall, G.R., ed.) pp. 653-655, ESCOM Leiden, 690 pgs.

Keeley, L.L., Hayes, T.K., Bradfield, J.Y. and Chung, J.S. (1989) Neuropeptides in Insect Control. In: Proceedings of a Conference on Biotechnology, Biological Pesticides and Novel Plant-Pest Resistance for Insect Pest Management, (eds. Roberts, D.W. and Granados, R.R.) pps. 99-106, Boyce Thompson Institute for Plant Research, Ithaca, NY, July 18-20, 1988. 175 pgs.

Keeley, L.L. (1990) Neuroendocrine Regulation of Fat Body Metabolism. In: Cockroaches as Models for Neurobiology: Applications in Biomedical Research. (eds. I. Huber, E.P. Masler and B. R. Rao), v. II, pps. 149-158. CRC Press, Boca Raton, FL, 326 pgs.

Keeley, L.L., Hayes, T.K. and Bradfield, J.Y. (1990) Insect Neuroendocrinology: Its Past, Its Present; Future Opportunities. In: Insect Neuroendocrinology and Neurophysiology • 1989 •, (ed. Borkovec, A.B. and Masler, E.P.), pp. 163-203, Humana, Clifton, NJ, 480 pgs.

Keeley, L.L., Hayes, T.K., Bradfield, J.Y. and Lee, Y.-H. (1991) Metabolic Neuropeptides, In: Insect Neuropeptides (Ed. Menn, J.J., Kelly, T.J. and Masler, E.P.), pp. 65-82, Amer. Chem. Soc. Symp. Series No. 453.

Keeley, L.L. (1991) Speculations on regulation of shrimp reproduction through peptide biotechnology. Proceedings, Second International Marine Biotechnology Conference, (IMBC '91), pg. 65.

Rankin, S.M., Bradfield, J.Y. and Keeley, L.L. (1992) Ovarian development in the South American white shrimp, Penaeus vannamei. In: Marine Ranching, Proceedings 18th U.S.-Japan Meeting on Aquaculture Port Ludlow, WA, 18-19 September, 1989, (ed. Svrjcek, R.) NOAA Tech. Report, NMFS 106, pgs. 27-33.

Keeley, L.L., Bradfield, J.Y., Sowa, S.M., Lee Y.-H. and Lu K.-H. (1994) Physiological actions of the hypertrehalosemic hormone in cockroaches. In: Perspectives in Comparative Endocrinology (eds. Davey, K.G., Peter, R.E. and Tobe, S.S.) pgs. 475-485., National Research Council Canada, Ottawa.

Lewis, D. K., Campbell, J.Q., Sowa, S.M., Chen, M.-E., Vinson, S.B. and Keeley, L.L. (2002) The biochemical characteristics of vitellogenin in the red imported fire ant, Solenopsis invicta (Hymenoptera: Apocrita: Formicidae). (Review from the Fire Ant Conference) Southwestern Entomologist, 25, 71-79.